Nucleic Acid Ther
L., Cnop M., BMC Genomics 2020, 21, 590
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Vascular and Cardiac Effects BPC-157 demonstrates significant cardiovascular effects in experimental models, including modulation of blood pressure, vascular tone, and cardiac protection following injury
In the context of GH and IGF-I physiology it can be concluded that 1) during childhood and adolescence the combined actions of GH and IGF-I in the presence of sufficient nutrition promote longitudinal growth and somatic maturation, 2) continued excess IGF-I activity in adulthood increases the risk for cardiovascular and neoplastic diseases and hence reduces longevity, 3) calorie restriction, which suppresses IGF-I activity and stimulates GH secretion, may promote longevity in human adults (82)